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Drug - Opioids

• Cocaine, Tramadol

• Mechanism of interference (known or expected): Uptake inhibition

• Suggested withdrawal prior to MIBG scintigraphy: 7-14 days

 

 

Drug - Tricyclic antidepressants

• Amitriptyline and derivates, imipramine and derivates, amoxapine, loxapine, doxepine, others…

• Mechanism of interference (known or expected): Uptake inhibition

• Suggested withdrawal prior to MIBG scintigraphy: 7-21 days

 

 

Drug - Sympathicomimetics*

• Phenylpropanolamine, pseudoephedrine, phenilephrine,amphetamine, dopamine, isoproterenol, salbutamol, terbutaline, phenoterol, xylometazoline

• Mechanism of interference (known or expected): Depletion of granules

• Suggested withdrawal prior to MIBG scintigraphy: 7-14 days

 

 

Drug - Antihypertensive/cardiovascular agents

• Labetalol, metoprolol, amiodarone

• Mechanism of interference (known or expected): Inhibition uptake and depletion

• Suggested withdrawal prior to MIBG scintigraphy: 21 days

 

• Reserpine

• Mechanism of interference (known or expected): Depletion and transport inhibition

• Suggested withdrawal prior to MIBG scintigraphy: 14 days

 

• Bretylium, guanethidine

• Mechanism of interference (known or expected): Depletion and transport inhibition

• Suggested withdrawal prior to MIBG scintigraphy: 14 days

 

• Calcium channel blockers: niphepidine, nicardipine, amlodipine

• Mechanism of interference (known or expected): Increased uptake and retention

• Suggested withdrawal prior to MIBG scintigraphy: 14 days

 

 

Drug - ACE inhibitors

• Captopril, Enalapril

• Mechanism of interference (known or expected): Increased uptake and retention

• Suggested withdrawal prior to MIBG scintigraphy: 14 days

 

 

Drug - Antipsychotics

• Phenothiazines° (chlorpromazine, promethazine, fluphenazine, others)

• Mechanism of interference (known or expected): Uptake inhibition

• Suggested withdrawal prior to MIBG scintigraphy: 21-28 days

 

• Thioxanthenes (maprotiline, trazolone)

• Mechanism of interference (known or expected): Uptake inhibition

• Suggested withdrawal prior to MIBG scintigraphy: 21-28 days

 

• Butyrophenones (droperidol, haloperidol)

• Mechanism of interference (known or expected): Uptake inhibition

• Suggested withdrawal prior to MIBG scintigraphy: 21-28 days

 

 

* components of bronchodilators, decongestants and diet aids.

° frequent components of antiemetic and antiallergic agents

 

Reference: http://www.snm.org.tw/Guideline/gl_onco_mibg.pdf